The Gravettian culture was one of the most widely distributed Upper Palaeolithic cultures across western Eurasia before the LGM19. The purified products were amplified in multiple 100l reactions using Herculase II Fusion DNA Polymerase (Agilent) following the manufacturers specifications with 0.3M of the IS5/IS6 primers. Each aDNA library was double indexed60 in 14 parallel 100l reactions using PfuTurbo DNA Polymerase (Agilent). Therefore,most of the ancestry found in these post-LGM individuals probably traced back to Gravettian-associated groups from western and southwestern Europe. Genomic structure in Europeans dating back at least 36,200 years. S. Shnaider received support from theRussian Science Foundation (no. In the box plot the centre line is the median, box bounds delineate the interquartile range and whiskers extend to maximum and minimum values, excluding outliers. Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. Lifetime access to all course materials and updates. About me. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. Charlton, S. et al. If you want to know more, you can always go to MySQLs data warehouse site. Learn with a sense of purpose. Its the complexity of product development, with all of its moving parts, that makes data immensely powerful. Tina teaches SQL in data science in addition to this basic material. The data here can also be structured or unstructured. Tina has 11 jobs listed on their profile. Can you tell I had fun filming this episode with Tina Huang, YouTube data science superstar (293k subscribers)? Both of these books focus on the science and math behind data mining. All remains were sampled with the approval of the institutions responsible for the analysis of archaeological material. You can also check out our video on the topic below or scroll down to keep on reading. Data Visualization Explained: Candlestick Chart, R Programming for Statistics and Data Science 2020. The newly reported individuals with over 15,000 SNPs on the Human Origins dataset are shown in black-outlined and filled symbols, as illustrated in the legend on the right, while representative ancient genomes are shown in outlined symbols, as illustrated in the legend at the bottom of the PCA. Archeol. ScienceDaily, 1 March 2023. In no time, she established herself as one of the favorite vloggers of the data community. The 10 mock interviews provide a great detailed approach to solving any SQL questions. 40, e3 (2012). Tina Huang, a data scientist currently working at a FAANG (Facebook, Amazon, Apple, Netflix, and Google Alphabet) company. From around 8ka, we begin to observe admixture events with Sidelkino ancestry in central Europe. Max Planck Institute for Evolutionary Anthropology. Tina Huang is a recent graduate of Stanford. Ice Age survivors. Illumina sequencing platforms were also used to sequence the 1240k and mtDNA captured libraries (Supplementary Data 1.B). In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a . 6). Both of these ancestries carry a genetic component distantly related to the Goyet Q116-1 individual dated to 35ka, with the Iberian individual also showing an affinity to the Villabruna cluster4,14. Your email address will not be published. | pros vs cons. Nucleic Acids Res. 12). 2932 and Supplementary Table 4). and D.C. have received funding from the Italian Ministry of University and Research (MUR) PRIN 2017 grants 20177PJ9XF and 20174BTC4R_002. Nat. 2, e190 (2006). University Universit Chouaib Doukkali; . Google Scholar. We love meeting interesting people and making new friends. Nat. Proc. Karmin, M. et al. Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. Runtime Collective Limited (trading as Brandwatch). CAS Great explanations and feels like real interviews that helps me warm up myself before the real interview! The oldest individual revealing an indistinguishable genetic profile from the Yuzhniy Oleniy Ostrov group is the 11ka Sidelkino individual from Samara in western Russia42. The two 14ka Oberkassel individuals mark the earliest presence of WHG ancestry north of the Alps, which we therefore rename the Oberkassel cluster(hereafter, Oberkassel cluster or ancestry), using the name of the oldest reported individual to date carrying such ancestry with more than one-fold coverage, for consistency4. The number of individuals in each group is written to the right of each bar. Survival of Late Pleistocene hunter-gatherer ancestry in the Iberian Peninsula. The aligned sequences of all individuals with new genomic data reported in this study are available at the European Nucleotide Archive (ENA) under study accession number PRJEB51862. It requires countless decisions to get them right, many of which have not been as straightforward at first. Rohland, N. & Hofreiter, M. Ancient DNA extraction from bones and teeth. 2011. Mittnik, A. et al. Once we have the data, we begin to tease out the high-impact insights. Teaching Assistant. In the MDS plot (Fig. I hope youve enjoyed reading this article. This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. Check out The data science resume that got me my FAANG job and subscribe to Tina Huangs YouTube channel. Protoc. Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. Charlene Hunter is a developer and an incredible advocate for increasing diversity in tech. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness . Quat. Interactions between people from central and eastern Europe can only be detected again from 8,000 years ago. The mitochondrial capture sequencing reads were cleaned by AdapterRemoval 2.2.0 to remove the adapters and reads with lengths below 30bp. ADS Rohland, N., Glocke, I., Aximu-Petri, A. Commun. We then removed samples with less than 0.04X coverage (calculated on the mappable, non-recombining region of the Y chromosome98) to avoid arbitrarily placing low-coverage samples at the root of major haplogroups. By using our site you agree toour The average calibrated date is shown, with pie charts indicating the estimated proportion of ancestry for each group or individual. Protoc. Present-day individuals (gray dots) genotyped on theHumanOrigins dataset are used to define the PCA variation onto which ancient genomes (coloured symbols) are projected. Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. 25, 459466 (2015). Nakatsuka, N. et al. Data warehousing is a field where you often have to deal with a lot of raw data. Feb 2015 - Jun 20161 year 5 months. 4. @hellotinah. This figure shows that the Gravettian-associated individuals from western Europe (Fournol cluster) are closely related to Goyet Q116-1 while the Gravettian-associated individuals from central-eastern and southern Europe (Vstonice cluster) are closely related to the Sunghir group, representative of the Kostenki cluster. A genome sequence from a modern human skull over 45,000 years old from Zlat k in Czechia. The pathway program not only helps students to strengthen their English, but more importantly, it helps students to understand and adapt to the expections of university.". The triangles show the average calibrated dates of the tested groups and the dots show the estimated admixture dates with the software DATES105 using Oberkassel (red dots) or Villabruna (blue dots) clusters as one source and ANE-related individuals as the other source population. Life During Adulthood: Should One Get Credit Cards? Int. 1). This suggests a very small recent effective population size, estimated to be in the order of around 70 individuals (Supplementary Table 2), causing the low genetic diversity in Sicilian Epigravettian hunter-gatherers. Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. No, there are no prerequisites for enrolling. Shes currently at Microsoft. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Here, we report genomic data from 4 individuals, including 3 approximately 13,000-year-old genomes from northeastern Italy (Pradis 1), northwestern Italy (Arene Candide 16) and Sicily (San Teodoro 2), as well as increased genome-wide coverage from Tagliente 215 dated to 17ka. The first horse herders and the impact of early Bronze Age steppe expansions into Asia. The tentative placements of low-coverage ancient individuals based on their haplogroup assignment (Supplementary Data 1.A) are indicated with arrows on the respective branches. They, along with it, will be accessible to you indefinitely. . PubMed Central Fifth, the Oberkassel ancestry in western and central Europe and the Sidelkino ancestry in eastern Europe remained largely isolated for almost 6,000 years until genetic interactions were first observedaround 8ka in northeastern Germany, possibly associated with cultural exchanges along the Baltics49 and around 7.5ka in the upper Volga region, possibly linked to the spread of pottery in the region50. The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. The dimensions are calculated using newly reported and previously published hunter-gatherer groups or individuals with more than 30,000 SNPs. 16, e2003703 (2018). CAS This is . Individuals with libraries showing signs of contamination were further tested using PMD-filtered bam files. Happy International Womens Day! The ethane yield of 35.4 mol/h with a high C 2 . http://creativecommons.org/licenses/by/4.0/, Ancient genomes show how humans escaped Europes deep freeze. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Billed once. 27 and 28). Other proposed climatic refugia for human survival during this period are the Italian peninsula, the Balkans and the southeastern European Plain, but the actual genetic contribution of populations from these regions to post-LGM Europeans is highly debated11,12,13. is supported by a Ramn y Cajal fellowship (RYC-2017-22558). Ancient Rome: A genetic crossroads of Europe and the Mediterranean. We provide five novel insights into the genomic history of hunter-gatherer populations over a time span of 30,000 years from the Upper Palaeolithic to the Neolithic. Follow Author. Ancient genomes indicate population replacement in Early Neolithic Britain. PubMedGoogle Scholar. The tool qpAdm 810 in ADMIXTOOLS 5.1 was applied to model the ancestries of admixed populations, with allsnps mode and the outgroup set selection described in Supplementary Information, section11. 864358 (to K.M. As inferred from the archaeological record35, the spread of the Magdalenian across Europe is linked to southwestern to northern and northeastern post-LGM population expansions and not to movements from southeastern refugia34. You have to deal with large datasets; however, you have to do your work in a way that makes sense to your team. Using f4-statistics and qpAdm, we confirm that EHG populations in eastern Europe are a mixture of Villabruna/Oberkassel and ANE ancestries (Supplementary Information, section11 and Supplementary Data 2.K). Freshwater radiocarbon reservoir effects at the burial ground of Minino, Northwest Russia. a, The genetic ancestry of hunter-gatherers dated between 14ka and 5.2ka modelled using qpAdm, with Oberkassel, Yuzhniy Oleniy Ostrov, Goyet Q-2 and Neolithic farmers from present-day Turkey (Barcn, Mentee and Boncuklu sites) representing Oberkassel (WHG) (blue), Sidelkino (EHG) (red), GoyetQ2 (orange) and Anatolian Neolithic farmer (green) ancestries, respectively. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. 6 and Supplementary Fig. In a rotator, samples were digested for at least 16h at 37C, and for pre-treated samples this was followed55 by an additional hour at 56C. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Thats it for today. Then pseudo-haploid genotypes were called using pileupCaller 1.4.0.2 (https://github.com/stschiff/sequenceTools) under random haploid calling mode. Biol. "Presumably, these people came from the Balkans, arrived first in northern Italy around the time of the glacial maximum and spread all the way south to Sicily.". Also if you want to see some cat pics. My name is Tina and I'm a data scientist and YouTuber. Nature (Nature) One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. An improved, lightweight and secure authentication scheme in context of fog-centric IoT communication is proposed in this paper to eradicate all the above mentioned security shortfalls of Wajid et al scheme. However, the extent to which groups associated with the Solutrean culture are in genetic continuity with earlier and later populations from the same region is unknown because no genomic data from Solutrean-associated individuals have been reported previously. Curr. On the basis of PCA and outgroup f3-statistics, the Neolithic Tutkaul 1 individual from Tajikistan is closely related to Upper Palaeolithic individuals from south-central Siberia (Afontova Gora 3 (AG3) and Malta 1), and roughly contemporaneous West Siberian hunter-gatherers (Tyumen and Sosnoviy), both carrying high proportions of ANE ancestry45 (Fig. Chintalapati, M., Patterson, N. & Moorjani, P. The spatiotemporal patterns of major human admixture events during the European Holocene. We also genotyped a selection of previously published individuals with the same approach (Supplementary Data 1.G)2,4,30,74,75,76,77,78. Antonio, M. L. et al. Li, H. & Durbin, R. Fast and accurate short read alignment with BurrowsWheeler transform. Article 8 Changes of Sidelkino and Oberkassel ancestry proportions in post-14 ka hunter-gatherers. Mol. A. Stoessel performed CT scanning and advised on sampling strategy. Sikora, M. et al. At the same time, these two groups started mixing with each other, and continued to do so for around 3,000 years," Krause says. Other individuals from that period, such as Zlat k from Czechia and UstIshim from Russia, do not carry significantly more Neanderthal ancestry than other non-African groups1,7, indicating differential interactions between Neanderthals and early modern humans during their initial expansions across Eurasia. This was confirmed with qpAdm, in which we could model all individuals from the Oberkassel cluster as a broadly constant mixture of approximately 75% Arene Candide 16 and 25% Goyet Q-2 (or 90% Arene Candide 16 and 10% Fournol 85) (Fig. Revise SQL essentials, improve your communication style and tackle the most challenging follow-up questions with ease. The analysis of biological relatedness was performed by calculating relatedness coefficient (r) based on PMR on the autosomal SNPs (Supplementary Data 1.F and Supplementary Information, section4). & Ringbauer, H. hapCon: estimating contamination of ancient genomes by copying from reference haplotypes. View Tina Zhang's business profile as Brand Specialist at Dymind Biotechnology. Become the most confident candidate in the room. Nat. In this admixture graph, the lineage related to Zlat k splits more basally than the Bacho Kiro IUP group, who contributes to Tianyuan, UstIshim and Goyet Q116-1 (indicated with red lines), but not to the Sunghir group. Evol. Error bars show 1s.e.m. & Nielsen, R. ANGSD: analysis of next generation sequencing data. Most Popular #86731. For consistency with the previously discussed nomenclature, we rename the EHG ancestryas the Sidelkino cluster(hereafter, Sidelkino cluster or ancestry). Adv. TV Actress. By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. Contrary to West Siberian hunter-gatherers, Tutkaul 1 does not carry an extra eastern Eurasian ancestry, but shows affinity to Iranian Neolithic farmers and some younger populations from Iran and the Turan region (Supplementary Data 2.L). Previously, she has interned at Goldman Sachs where she used Python and Scala to implement machine learning techniques for automated anomaly detection. This means you will have no set time limit for completing any of the modules or assignments. Reviews. 31, 29732983.e9 (2021). I can't believe we finally got to meet in person. Open access funding provided by Max Planck Society. Showcase your skills and bolster your data science credentials. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. Taiwan Patent Application M401603, filed 11th April . Article Goutas, N. in Les Gravettiens (ed. ), no. Bilateral trade between China and Russia in 2022 rose 34.3% year-on-year to a record high of 1.28 trillion yuan ($190 billion) in yuan-denominated terms, Chinese customs data showed in early January. 3.Tina Huang. An early modern human from Romania with a recent Neanderthal ancestor. However, the research team found no evidence for this, on the contrary: hunter-gatherer populations associated with the Gravettian culture and living in central and southern Europe are no longer genetically detectable after the LGM. Write for us- Weird Science, Energy & Minerals Guest Post. Here we will provide you only interesting content, which you will like very much. We can have either structured data (e.g. The genetic affinity to the Villabruna ancestry is present in El Mirn and in Magdalenian-associated individuals from western and central Europe. This is first detected in an individual from Gross Fredenwalde in northeastern Germany and reaches around 10% in most European hunter-gatherer individuals thereafter (Extended Data Fig. About the Instructor. 15, 22792300 (2020). Science 365, eaat7487 (2019). Author pages are created from data sourced from our academic publisher partnerships and public sources. The grouping of Epigravettian-associated populations is shown with the same colour in a. 26, 827833 (2016). It is often considered as a pan-European cultural mosaic with regional variations in material to symbolic productions20,21. 18 and Supplementary Data 2.O), suggests the Balkans as a source of the incoming Epigravettian-associated population. Evol. 1 and 2). Radiocarbon 51, 337360 (2009). 724703 and no. Population genomics of Mesolithic Scandinavia: investigating early postglacial migration routes and high-latitude adaptation. Meet Tina Huang. 132, Tables 14 and references. Think about some of your favorite apps today: Instagram, Uber, Facebook, and YouTube. USA 116, 16391644 (2019). Science 360, 548552 (2018). 5, 820825 (2021). Int. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. 3b). Nat. Tina Huang is very empowering, and she knows what she is talking about. "Further interdisciplinary research will clarify which exact processes were responsible for the genetic replacements of entire Ice Age populations.". Extended Data Fig. We visualize the total amount of ROH longer than 4 cM for (a) pre-LGM individuals, (b) Epigravettian- and Magdalenian-associated individuals, (c) individuals carrying high proportions of Sidelkino-related ancestry, and (d) individuals carrying high proportions of Oberkassel-related ancestry. El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). Mathieson, I. et al. . Fu, Q. et al. View Tina_Huang_Resume_i.pdf from HCI 445 at DePaul University. October 28 Actress #31. Ecol. Curr. Biol. Echinacea. Shes also the creator of the Microsoft Excel spreadsheet Data Mining 101. She has also published a book titled Data Science: Principles and Practices which she wrote with co-author Dan Ariely. Individuals in western and southwestern Europe related to the Fournol cluster are consistently deposited in cave sites and occasionally exhibit anthropogenic marks whereas individuals related to the Vstonice cluster are buried with grave goods and/or personal ornaments and ochre in open air or cave sites in central-eastern and southern Europe, respectively (Supplementary Figs. This raises the possibility that the replacement by the Oberkassel cluster and the formation of the Sidelkino cluster might have been the result of population expansions influenced by the abrupt warming during the BllingAllerd interstadial4,24. Created by DataSciencePR. This course is presenting itself as both a refresher and a challenge. ADS As recommended, we analysed individuals with over 400,000 SNPs called on the 1240k panel101 and we called ROH longer than 4cM (Supplementary Data 3.B). An equimolar pool of all libraries was then prepared for shotgun sequencing on Illumina Hiseq4000 platform using 75bp single-end reads for screening. Its not just the top 200 that this competition attracts, but anyone interested in data science. 7 and Supplementary Table 3), which coincides roughly with the first appearance of the Oberkassel ancestry in central Europe. We show that all analysed Epigravettian-associated individuals carry a homogeneous Villabruna ancestry, with the intra-group genetic structure mainly determined by their geographical, and not temporal, distribution. Ecol. Late Upper Palaeolithic hunter-gatherers in the Central Mediterranean: new archaeological and genetic data from the Late Epigravettian burial Oriente C (Favignana, Sicily). I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. A 5700 year-old human genome and oral microbiome from chewed birch pitch. Tina Huang, a data scientist currently working at a FAANG (Facebook, Amazon, Apple, Netflix, and Google Alphabet) company. CAS Paradis, E., Claude, J. de Lige, 2021). The White House and federal agencies in the U.S. declare the Year of Open Science, listing several actions towards open science. National Science Council feb. 2009 - feb. 2009 1 maand. The bivariate plots show the expansion of Oberkassel and Sidelkino ancestries through time in two European areas (longitude below and above 30 degrees). Nature 505, 8791 (2014). Big Data, Data Mining, and Machine Learning (Jared Dean) . Srie Prhistoire dEurope 9 (ditions, 2001). Nature 536, 419424 (2016). In it, we laugh while discussing how to get started in data science and her learning/productivity tricks.Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Previously worked at Goldman Sachs and the Ontario Institute for Cancer Research. Holds a Masters in Computer and Information Technology from the University of Pennsylvania and a bachelors in Pharmacology from the University of TorontoIn this episode, Tina details: Her guidance for preparing for a career in data science from scratch. Her five steps for consistently doing anything. Her strategies for learning effectively and efficiently. What the day-to-day is like for a data scientist at one of the worlds largest tech companies. The software languages she uses regularly. Her SQL course. How her science and computer science backgrounds help her as a data scientist today.Todays episode should be appealing to a broad audience, whether youre thinking of getting started in data science, are already an experienced data scientist, or youre more generally keen to pick up career and productivity tips from a light-hearted conversation.Thanks to Serg Mass, Brindha Ganesan and Ken Jee for providing questions for Tina in Ken's case, a very silly question indeed.The SuperDataScience show's available on all major podcasting platforms, YouTube, and at SuperDataScience.com.